DICHLOROACETIC ANHYDRIDE
Names
[ CAS No. ]:
4124-30-5
[ Name ]:
DICHLOROACETIC ANHYDRIDE
[Synonym ]:
(2,2-dichloroacetyl) 2,2-dichloroacetate
EINECS 223-924-8
MFCD00000842
Dichloroacetic anhydride
Chemical & Physical Properties
[ Density]:
1.695g/cm3
[ Boiling Point ]:
215ºC at 760mmHg
[ Melting Point ]:
-30ºC
[ Molecular Formula ]:
C4H2Cl4O3
[ Molecular Weight ]:
239.86900
[ Flash Point ]:
90.6ºC
[ Exact Mass ]:
237.87600
[ PSA ]:
43.37000
[ LogP ]:
1.66360
[ Appearance of Characters ]:
Liquid After Melting | Clear colorless
[ Index of Refraction ]:
n20/D 1.483(lit.)
[ Storage condition ]:
Store below +30°C.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AG6300000
- CHEMICAL NAME :
- Acetic acid, dichloro-, anhydride
- CAS REGISTRY NUMBER :
- 4124-30-5
- BEILSTEIN REFERENCE NO. :
- 0512173
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C4-H2-Cl4-O3
- MOLECULAR WEIGHT :
- 239.86
- WISWESSER LINE NOTATION :
- GYGVOVYGG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,574,1986 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2820 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 470 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951
Safety Information
[ Symbol ]:
GHS05, GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H311-H314-H332
[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
C
[ Risk Phrases ]:
R21;R34
[ Safety Phrases ]:
S26;S27;S28;S45;S36/S37/S39
[ RIDADR ]:
UN 2923 8/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
AG6300000
[ Packaging Group ]:
II
[ HS Code ]:
2915900090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2915900090
[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%
Articles
Toxicol. Appl. Pharmacol. 216(2) , 248-55, (2006)
Dichloroacetyl chloride (DCAC) is formed from trichloroethene (TCE), which is implicated in inducing/accelerating autoimmune response. Due to its potent acylating activity, DCAC may convert proteins t...
Selective enzymatic acylation of 10-deacetylbaccatin III. Lee D, et al.Tetrahedron Lett. 39(49) , 9039-42, (1998)
A new soluble and hydrolytically cleavable intermediate in cellulose functionalization: cellulose dichloroacetate (CDCA). Liebert T and Klemm D.
Acta Polym. 49(2-3) , 124-28, (1998)