Medioresil

Names

[ Name ]:
Medioresil

[Synonym ]:
5-methoxypinoresinol
5-methoxyphenylhydrazine hydrochloride
4-[(1S,3aR,4S,6aR)-4-(4-Hydroxy-3-methoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2,6-dimethoxyphenol
Phenol, 2,6-dimethoxy-4-[(1S,3aR,4S,6aR)-tetrahydro-4-(4-hydroxy-3-methoxyphenyl)-1H,3H-furo[3,4-c]furan-1-yl]-
m-methoxyphenylhydrazine hydrochloride

Biological Activity

[Description]:

(+)-Medioresinol is a furofuran type lignan with antifungal, antibacterial and lesishmanicidal activities. (+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans. (+)-Medioresinol can reduce the cardiovascular disease risk[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cardiovascular Disease

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Research Areas >> Neurological Disease

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Ji Hong Hwang, et al. (+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans. Biochimie. 2012 Aug;94(8):1784-93.

[2]. Ji Hong Hwang, et al. Synergistic antibacterial and antibiofilm effect between (+)-medioresinol and antibiotics in vitro. Appl Biochem Biotechnol. 2013 Aug;170(8):1934-41.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
575.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₄O₇

[ Molecular Weight ]:
388.411

[ Flash Point ]:
302.0±30.1 °C

[ Exact Mass ]:
388.152191

[ PSA ]:
86.61000

[ LogP ]:
1.12

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.587

Precursor & DownStream

Precursor

DownStream

Related Compounds

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