3'-O-TBDMS-dT

Names

[ Name ]:
3'-O-TBDMS-dT

[Synonym ]:
3'-DiTBSRiboT
TBS-T
3'-O-TBDMS-dT

Biological Activity

[Description]:

3’-O-t-Bulyldimethylsilylthymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₂₈N₂O₅Si

[ Molecular Weight ]:
356.49

[ Exact Mass ]:
356.17700

[ PSA ]:
93.55000

[ LogP ]:
1.51520

3'-O-TBDMS-dT

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds