3'-O-TBDMS-dT

Modify Date: 2025-08-25 11:08:07

3'-O-TBDMS-dT structure	Common Name	3'-O-TBDMS-dT
	CAS Number	40733-27-5	Molecular Weight	356.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₂₈N₂O₅Si	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 3'-O-TBDMS-dT

3’-O-t-Bulyldimethylsilylthymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	1-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
Synonym	More Synonyms

Description	3’-O-t-Bulyldimethylsilylthymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Molecular Formula	C₁₆H₂₈N₂O₅Si
Molecular Weight	356.49
Exact Mass	356.17700
PSA	93.55000
LogP	1.51520

Precursor 9
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DownStream 5
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