H-Hyp-OMe hydrochloride

Names

[ Name ]:
H-Hyp-OMe hydrochloride

[Synonym ]:
Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1)
Trans-4-hydroxy-L-proline methyl ester hydrochloride
Methyl (4R)-4-hydroxy-L-prolinate hydrochloride (1:1)
L-Proline, 4-hydroxy-, methyl ester, (4R)-, hydrochloride (1:1)
Trans-4-Hydroxy-L-Proline Methyl Ester,Hydrochloride Salt
(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic Acid Methyl Ester Hydrochloride
Methyl 4-hydroxyprolinate hydrochloride (1:1)
L-4-Hydroxyproline methyl ester hydrochloride
Methyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate
Methyl (2S,4R)-4-Hydroxypyrrolidine-2-carboxylate Hydrochloride
H-Hyp-OMe·HCl
methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride
MFCD00080855
H-Hyp-OMe．HCl
trans-4-Hydroxy-L-proline methylester hydrochloride

Biological Activity

[Description]:

H-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]<

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Boiling Point ]:
247.2ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₁₂ClNO₃

[ Molecular Weight ]:
181.617

[ Flash Point ]:
103.3ºC

[ Exact Mass ]:
181.050568

[ PSA ]:
58.56000

[ LogP ]:
0.01300

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%