Boc-Hyp-OH

Names

[ Name ]:
Boc-Hyp-OH

[Synonym ]:
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2S)-
trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline
BOC-HYP-OH
N-ter
trans-Boc-Hyp-OH
BOC-L-HYP-OH
BOC-HYP
N-BOC-L-Hydroxyproline
RARECHEM EM WB 0136
trans-N-tert-Butoxycarbonyl-4-hydroxy-l-proline
BOC-L-4-HYDROXYPROLINE
BOC-trans-4-hydroxy-L-proline
BOC-TRANS-HYP-OH
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2S,4R)-
(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
MFCD00053370
trans-N-Boc-4-hydroxy-L-proline
BOC-HYDROXYPROLINE
(4R)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline
4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline
1-(tert-Butoxycarbonyl)-4-hydroxy-L-proline

Biological Activity

[Description]:

Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
390.9±42.0 °C at 760 mmHg

[ Melting Point ]:
123-127 °C(lit.)

[ Molecular Formula ]:
C₁₀H₁₇NO₅

[ Molecular Weight ]:
231.246

[ Flash Point ]:
190.2±27.9 °C

[ Exact Mass ]:
231.110672

[ PSA ]:
87.07000

[ LogP ]:
-0.71

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.531

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%