8-Azanebularine

Names

[ Name ]:
8-Azanebularine

[Synonym ]:
8-azanebularine
1-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl-β-D-1-deoxy-ribofuranose
(2R,3S,4R,5R)-2-Hydroxymethyl-5-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl-tetrahydro-furan-3,4-diol
8-Azanebutarin

Biological Activity

[Description]:

8-Azanebularine, a compound with hydrogen in place of the C6 amino group, inhibits the ADAR2 reaction at high concentrations (IC50=15 mM). 8-Azanebularine is incorporated into an RNA structure recognized by human ADAR2 results in high-affinity binding (KD=2 nM). 8-Azanebularine can be used for the research of ADAR-catalyzed RNA-editing reaction[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[Target]

ADAR2 reaction:15 mM (IC50)

ADAR2:2 nM (Kd)

[References]

[1]. Haudenschild BL, et al. A transition state analogue for an RNA-editing reaction. J Am Chem Soc. 2004;126(36):11213-11219.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₁₁N₅O₄

[ Molecular Weight ]:
253.21500

[ Exact Mass ]:
253.08100

[ PSA ]:
126.41000

Related Compounds

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