8-(Phenylmethoxy)guanosine

Names

[ Name ]:
8-(Phenylmethoxy)guanosine

[Synonym ]:
8-Benzyloxy-guanosin

Biological Activity

[Description]:

8-(Phenylmethoxy)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

Chemical & Physical Properties

[ Density]:
1.8g/cm3

[ Boiling Point ]:
772ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₁₉N₅O₆

[ Molecular Weight ]:
389.36

[ Flash Point ]:
420.7ºC

[ Exact Mass ]:
389.13400

[ PSA ]:
168.74000

[ Index of Refraction ]:
1.796

8-(Phenylmethoxy)guanosine

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream