(+)-BICUCULLINE METHOCHLORIDE
Names
[ CAS No. ]:
38641-83-7
[ Name ]:
(+)-BICUCULLINE METHOCHLORIDE
[Synonym ]:
HMS3266A09
UNII-I3UNE1K4AF
N-Me-bicuculline
Bisculline methyl chloride
Biological Activity
[Description]:
[Related Catalog]:
[Target]
IC50: 3 μM (GABAA)[3]
[In Vitro]
[In Vivo]
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C21H20ClNO6
[ Molecular Weight ]:
417.84000
[ Exact Mass ]:
417.09800
[ PSA ]:
63.22000
MSDS
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Safety Phrases ]:
24/25
[ RIDADR ]:
UN 1544 6.1/PG 2
Articles
Anesthesiology 93(6) , 1474-81, (2000)
The activity of canine expiratory (E) neurons in the caudal ventral respiratory group is primarily dependent on N-methyl-D-aspartic acid (NMDA) receptor-mediated excitatory chemodrive inputs and modul...
Influence of genuine kavapyrone enantiomers on the GABA-A binding site.Planta Med. 64(6) , 504-6, (1998)
The influence of kavapyrones from Piper methysticum Forst. on the GABAA receptor was demonstrated using radioreceptor assays. Both the dienolide yangonin and the genuine enolide enantiomers (+)-kavain...
Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity.Brain Res. 646(2) , 235-41, (1994)
We examined the interactions of D,L-laudanosine, a potentially epileptogenic metabolite of the neuromuscular relaxant atracurium besylate, with gamma-aminobutyric acid (GABA) and opioid binding sites,...