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(1,2,3,4,5,6,7,8-2H8)-9H-Carbazole

Names

[ CAS No. ]:
38537-24-5

[ Name ]:
(1,2,3,4,5,6,7,8-2H8)-9H-Carbazole

[Synonym ]:
(1,2,3,4,5,6,7,8-H)-9H-Carbazole
carbazole d8
9H-Carbazole-1,2,3,4,5,6,7,8-d
carbazole-d8,nh

Biological Activity

[Description]:

Carbazole-d8 is the deuterium labeled Carbazole (HY-D0204). Carbazole is a tricyclic aromatic heterocyclic. Carbazole can form a new type of DNA minor groove complex to suppress the synthesis of new DNA or RNA[1][2].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Research Areas >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. F A Tanious, et al. A new type of DNA minor-groove complex: carbazole dication-DNA interactions. Biochemistry. 1997 Dec 9;36(49):15315-25.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
355.0±11.0 °C at 760 mmHg

[ Molecular Formula ]:
C12HD8N

[ Molecular Weight ]:
175.256

[ Flash Point ]:
160.0±11.9 °C

[ Exact Mass ]:
175.123718

[ PSA ]:
15.79000

[ LogP ]:
3.72

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.768

Related Compounds