Coumarin VI

Names

[ Name ]:
Coumarin VI

[Synonym ]:
Coumarin 6,laser grade
EINECS 253-830-2
3-(2-Benzothiazolyl)-N,N-diethylumbelliferylamine (3-(2-Benzothiazolyl)-7-(diethylamino)coumarin
coumarin-540
3-(1,3-benzothiazol-2-yl)-7-(diethylamino)chromen-2-one
3-(benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one
MFCD00041869
3-(2-Benzothiazolyl)-7-(diethylamino)coumarin
3-(2-benzothiazolyl)-7-(diethylamino)-2H-1-benzopyran-2-one
3-benzothiazol-2-yl-7-(diethylamino)chromen-2-one
3-(1,3-benzothiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one
3-(Benzothiazo-2-yl)-7-(diethylamino)-2H-chromen-2-one
2H-1-Benzopyran-2-one,3-(2-benzothiazolyl)-7-(diethylamino)

Biological Activity

[Description]:

Coumarin 6, a fluorescent dye, is used as a fluorescent probe in a microparticle drug delivery system to conduct in vivo tracking, cell uptake, and transport mechanism studies of drug delivery systems[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Elizebeth Purr, et al. Preparation of PLGA Nanoparticles Encapsulated with Fluorescent Probe Coumarin-6. bioRxiv preprint first posted online Apr. 23, 2019.

Chemical & Physical Properties

[ Density]:
1.311 g/cm3

[ Boiling Point ]:
570.1ºC at 760 mmHg

[ Melting Point ]:
208-210 °C(lit.)

[ Molecular Formula ]:
C₂₀H₁₈N₂O₂S

[ Molecular Weight ]:
350.43400

[ Flash Point ]:
298.6ºC

[ Exact Mass ]:
350.10900

[ PSA ]:
74.58000

[ LogP ]:
4.91590

[ Index of Refraction ]:
1.69

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
NEGLIGIBLE

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S22-S24/25-S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Herceptin conjugated PLGA-PHis-PEG pH sensitive nanoparticles for targeted and controlled drug delivery.

Int. J. Pharm. 487 , 81-90, (2015)

A dual functional nano-scaled drug carrier, comprising of a targeting ligand and pH sensitivity, has been made in order to increase the specificity and efficacy of the drug delivery system. The nanopa...

Positive-charged solid lipid nanoparticles as paclitaxel drug delivery system in glioblastoma treatment.

Eur. J. Pharm. Biopharm. 88(3) , 746-58, (2015)

Paclitaxel loaded solid lipid nanoparticles (SLN) of behenic acid were prepared with the coacervation technique. Generally, spherical shaped SLN with mean diameters in the range 300–600 nm were obtain...

Bioactive Hybrid Particles from Poly(D,L-lactide-co-glycolide) Nanoparticle Stabilized Lipid Droplets.

ACS Appl. Mater. Interfaces 7 , 17460-70, (2015)

Biodegradable and bioactive hybrid particles composed of poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles and medium-chain triglycerides were prepared by spray drying lipid-in-water emulsions stabi...