Arimoclomol citrate

Names

[ Name ]:
Arimoclomol citrate

[Synonym ]:
Arimoclomol citrate [MI]
UNII-Q85FFY6179
Arimoclomol citrate
3-Pyridinecarboximidoyl chloride,N-((2R)-2-hydroxy-3-(1-piperidinyl)propoxy)-,1-oxide,2-hydroxy-1,2,3-propanetricarboxylate (1:1)

Biological Activity

[Description]:

Arimoclomol citrate (BRX-220 citrate) is a co-inducer of heat shock proteins (HSP)[1]. Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HSP

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

[Target]

HSP

[In Vivo]

Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis[1]. Animal Model: Male Wistar rats weighing 240 to 270 g[1] Dosage: 20 mg/kg Administration: Administered intragastrically, for 5 days Result: Had a protective effect against CCK-induced acute pancreatitis.

[References]

[1]. Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92.

[2]. Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₈ClN₃O₁₀

[ Molecular Weight ]:
505.90300

[ Exact Mass ]:
505.14600

[ PSA ]:
202.65000

[ LogP ]:
0.56830

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.