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Arimoclomol citrate

Names

[ CAS No. ]:
368860-21-3

[ Name ]:
Arimoclomol citrate

[Synonym ]:
Arimoclomol citrate [MI]
UNII-Q85FFY6179
Arimoclomol citrate
3-Pyridinecarboximidoyl chloride,N-((2R)-2-hydroxy-3-(1-piperidinyl)propoxy)-,1-oxide,2-hydroxy-1,2,3-propanetricarboxylate (1:1)

Biological Activity

[Description]:

Arimoclomol citrate (BRX-220 citrate) is a co-inducer of heat shock proteins (HSP)[1]. Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HSP
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Research Areas >> Metabolic Disease
Research Areas >> Neurological Disease

[Target]

HSP


[In Vivo]

Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis[1]. Animal Model: Male Wistar rats weighing 240 to 270 g[1] Dosage: 20 mg/kg Administration: Administered intragastrically, for 5 days Result: Had a protective effect against CCK-induced acute pancreatitis.

[References]

[1]. Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92.

[2]. Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H28ClN3O10

[ Molecular Weight ]:
505.90300

[ Exact Mass ]:
505.14600

[ PSA ]:
202.65000

[ LogP ]:
0.56830

Related Compounds