N,N,N',N'-TETRAMETHYLBENZIDINE

Names

[ CAS No. ]:
366-29-0

[ Name ]:
N,N,N',N'-TETRAMETHYLBENZIDINE

[Synonym ]:
4,4'-Bis(dimethylamino)biphenyl
N,N,N′,N′-Tetramethylbenzidine
N,N,N‘,N‘-Tetramethylbenzidine
4-[4-(dimethylamino)phenyl]-N,N-dimethylaniline
MFCD00008310
N,N,N',N'-Tetramethylbenzidine
EINECS 206-676-5

Chemical & Physical Properties

[ Density]:
1.041g/cm3

[ Boiling Point ]:
387.1ºC at 760 mmHg

[ Melting Point ]:
193-195 °C(lit.)

[ Molecular Formula ]:
C₁₆H₂₀N₂

[ Molecular Weight ]:
240.34300

[ Flash Point ]:
173.4ºC

[ Exact Mass ]:
240.16300

[ PSA ]:
6.48000

[ LogP ]:
3.48560

[ Index of Refraction ]:
1.605

[ Stability ]:
Stable. Incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD1752100

CHEMICAL NAME :: Benzidine, N,N,N',N'-tetramethyl-

CAS REGISTRY NUMBER :: 366-29-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H20-N2

MOLECULAR WEIGHT :: 240.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 nmol/plate

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10,263,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8275 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 21 (estimated) No. of Female Employees: 21 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi,Xn

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin . R40:Limited evidence of a carcinogenic effect. R22:Harmful if swallowed.

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DD1752100

[ HS Code ]:
2921590090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921590090

[ Summary ]:
2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Loss of Endocan tumorigenic properties after alternative splicing of exon 2.

BMC Cancer 8 , 14, (2008)

Endocan was originally described as a dermatan sulfate proteoglycan found freely circulating in the blood. Endocan expression confers tumorigenic properties to epithelial cell lines or accelerate the ...

A triple-labeling method: HRP anterograde tract tracing combined with double immunofluorescent cell staining in developing neural tissue of the rat.

J. Neurosci. Methods 30 , 71, (1989)

In this paper we describe a triple-labeling technique on a single section of developing nervous tissue. This labelling consists of a histochemical visualization of anterogradely transported horseradis...

Glutathione conjugate formation without N-demethylation during the peroxidase catalysed N-oxidation of N,N',N,N'-tetramethylbenzidine.

Chem. Biol. Interact. 61(1) , 61-74, (1987)

The mechanism of peroxidative N-dealkylation of alkylamines proceeds via one-electron oxidation to the iminium cation which reacts with water to give the N-hydroxymethyl derivative which decomposes to...