G3335

Names

[ Name ]:
G3335

[Synonym ]:
PPARgamma Antagonist III,G3335
IN1159
TRP-GLU
tryptophylglutamic acid
L-tryptophyl-L-glutamic acid
H-Trp-Glu-OH
PPARg Antagonist III,G3335

Biological Activity

[Description]:

H-Trp-Glu-OH is a selective, reversible and cell-permeable PPARγ with a Kd of ~8 µM. H-Trp-Glu-OH might be developed as a possible lead compound in diabetes research[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR

Research Areas >> Metabolic Disease

[Target]

PPARγ:8 μM (Kd)

[References]

[1]. Ye F, et al. The dipeptide H-Trp-Glu-OH shows highly antagonistic activity against PPARgamma: bioassay with molecular modeling simulation. Chembiochem. 2006 Jan;7(1):74-82.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₉N₃O₅

[ Molecular Weight ]:
333.33900

[ Exact Mass ]:
333.13200

[ PSA ]:
145.51000

[ LogP ]:
1.56310

[ Storage condition ]:
-20℃

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%