N-(Hydroxymethyl)nicotinamide
Names
[ CAS No. ]:
3569-99-1
[ Name ]:
N-(Hydroxymethyl)nicotinamide
[Synonym ]:
Pyridine-3-carboxylic Acid N-Methylolamide
3-Pyridinecarboxamide, N-(hydroxymethyl)-
Nicodine
Bilizorin
Cholamid
EINECS 222-668-4
Bilamid
3-Pyridinecarboxylic acid N-hydroxymethylamide
Nicoform
Cholamide
MFCD00010437
Nikomethamide
N-(hydroxymethyl)pyridine-3-carboxamide
Bilocid
N-(Hydroxymethyl)nicotinamide
Nicodin
hydroxymethylnicotinamide
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
427.7±25.0 °C at 760 mmHg
[ Melting Point ]:
152-154 °C(lit.)
[ Molecular Formula ]:
C7H8N2O2
[ Molecular Weight ]:
152.151
[ Flash Point ]:
212.5±23.2 °C
[ Exact Mass ]:
152.058578
[ PSA ]:
62.22000
[ LogP ]:
-0.80
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.569
[ Storage condition ]:
-20?C Freezer
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QS4476500
- CHEMICAL NAME :
- Nicotinamide, N-(hydroxymethyl)-
- CAS REGISTRY NUMBER :
- 3569-99-1
- BEILSTEIN REFERENCE NO. :
- 0128633
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C7-H8-N2-O2
- MOLECULAR WEIGHT :
- 152.17
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.305- 1972- Volume(issue)/page/year: 305,427,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 17,73,1960
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
QS4476500
[ HS Code ]:
2933399090
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933399090
[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Yao Xue Xue Bao 27(8) , 629-31, (1992)
N-Hydroxymethyl-nicotinamide, an antimicrobic agent was prepared in good yield by treating nicotinamide with excess of formaldehyde in the presence of potassium carbonate. The condensation reaction wa...
Thin-layer chromatography-densitometric measurements for determination of N-(hydroxymethyl)nicotinamide in tablets and stability evaluation in solutions.J. AOAC Int. 91(5) , 1186-90, (2008)
A thin-layer chromatography (TLC)-densitometric method was developed to determine N-(hydroxymethyl)nicotinamide in tablets and basic solutions along with nicotinic acid. Analysis was performed on sili...