Natsudaidain

Names

[ Name ]:
Natsudaidain

[Synonym ]:
3-hydroxy-5,6,7,8,3',4'-hexamethoxyflavone
3-Hydroxy-3',4',5,6,7,8-hexamethoxyflavone
3-hydroxynobiletin
Natsudaidain

Biological Activity

[Description]:

Natsudaidain is a kind of polymethoxyflavone. Natsudaidain can be isolated from Citrus plants. Natsudaidain inhibits tumor necrosis factor-α and cyclooxygenase-2 production n by suppressing p38 MAPK phosphorylation on mast cells[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK

[References]

[1]. Takuya Matsui, et al. Effect of natsudaidain isolated from Citrus plants on TNF-α and cyclooxygenase-2 expression in RBL-2H3 cells. Journal of Pharmacy and Pharmacology. 2009, 61, 1.

Chemical & Physical Properties

[ Density]:
1.314g/cm3

[ Boiling Point ]:
608.3ºC at 760mmHg

[ Molecular Formula ]:
C₂₁H₂₂O₉

[ Molecular Weight ]:
418.39

[ Flash Point ]:
212.3ºC

[ Exact Mass ]:
418.12600

[ PSA ]:
105.82000

[ LogP ]:
3.21720

[ Index of Refraction ]:
1.579

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%