DL-Dithiothreitol

Names

[ Name ]:
DL-Dithiothreitol

[Synonym ]:
DITHIOERYTHRITOL
DL-1,4-Dithiothreitol
DTT
1,4-Dithiothreitol
1,4-Bissulfanylbutane-2,3-diol
DL-1,4-Dimercapto-2,3-dihydroxybutane
2,3-Butanediol, 1,4-dimercapto-, (2S,3S)-
THREO-2,3-DIHYDROXY-1,4-DITHIOLBUTANE
1,4-Disulfanyl-2,3-butanediol
Threitol, 1,4-dithio-
(R*,R*)-1,4-DIMERCAPTO-2,3-BUTANEDIOL
EINECS 222-468-7
(2S,3S)-1,4-Disulfanyl-2,3-butanediol
Cleland's Reagent
DL-Dithiothreitol
(2R*,3S*)-1,4-dimercaptobutane-2,3-diol
(2S,3S)-1,4-Disulfanylbutane-2,3-diol
threo-2,3-Dihydroxy-1,4-butanedithiol
dithiothreitol
(2R*,3S*)-1,4-dimercapto-2,3-butanediol
Sputolysin
threo-1,4-Dimercapto-2,3-butanediol
1,4-Disulfanylbutane-2,3-diol
2,3-Butanediol, 1,4-dimercapto-
MFCD00004877
(±)-1,4-Dimercapto-2,3-butanediol

Biological Activity

[Description]:

DTT is a small-molecule redox reagent.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Biochemical Assay Reagents

Research Areas >> Others

[References]

[1]. Dithiothreitol, From Wikipedia

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
364.5±42.0 °C at 760 mmHg

[ Melting Point ]:
38-43ºC

[ Molecular Formula ]:
C₄H₁₀O₂S₂

[ Molecular Weight ]:
154.251

[ Flash Point ]:
174.2±27.9 °C

[ Exact Mass ]:
154.012222

[ PSA ]:
118.06000

[ LogP ]:
0.07

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.579

[ Storage condition ]:
2-8°C

[ Stability ]:
Stability Stable, but heat sensitive. Incompatible with strong oxidizing agents. Keep frozen at -20 to -10 C.

[ Water Solubility ]:
H2O: 50 mg/mL, clear, colorless | freely soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK1610000

CHEMICAL NAME :: 2,3-Butanediol, 1,4-dimercapto-, D-threo-

CAS REGISTRY NUMBER :: 3483-12-3

LAST UPDATED :: 199707

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C4-H10-O2-S2

MOLECULAR WEIGHT :: 154.26

WISWESSER LINE NOTATION :: SH1YQYQ1SH -D,THREO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 154 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 94,1419,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 108 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 1,576,1949 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7467 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1196 (estimated) No. of Female Employees: 906 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
UN 3335

[ WGK Germany ]:
3

[ RTECS ]:
EK1610000

[ HS Code ]:
2930909090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Immunomodulation by the Pseudomonas syringae HopZ type III effector family in Arabidopsis.

PLoS ONE 9(12) , e116152, (2014)

Pseudomonas syringae employs a type III secretion system to inject 20-30 different type III effector (T3SE) proteins into plant host cells. A major role of T3SEs is to suppress plant immune responses ...

Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy.

Biomaterials 51 , 1-11, (2015)

Targeting cancer metabolism is emerging as a successful strategy for cancer therapy. However, most of the marketed anti-metabolism drugs in cancer therapy do not distinguish normal cells from cancer c...

A new enabling proteomics methodology to investigate membrane associated proteins from parasitic nematodes: case study using ivermectin resistant and ivermectin susceptible isolates of Caenorhabditis elegans and Haemonchus contortus.

Vet. Parasitol. 207(3-4) , 266-75, (2015)

The mechanisms involved in anthelmintic resistance (AR) are complex but a greater understanding of AR management is essential for effective and sustainable control of parasitic helminth worms in lives...