Doxepin D3 Hydrochloride

Names

[ Name ]:
Doxepin D3 Hydrochloride

[Synonym ]:
1-Propanamine, 3-dibenz[b,e]oxepin-11(6H)-ylidene-N-methyl-N-(methyl-d)-, hydrochloride (1:1)
3-(Dibenzo[b,e]oxepin-11(6H)-ylidene)-N-methyl-N-(H)methyl-1-propanamine hydrochloride (1:1)
3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N-methyl-N-(trideuteriomethyl)propan-1-amine,hydrochloride
Doxepin-d3Hydrochloride

Biological Activity

[Description]:

Doxepin D3 Hydrochloride is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant used as a sedative. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

Histamine receptor H1; CYP450 2C19 and CYP450 1A2[2]

[References]

[1]. Hajak, G., et al., Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. J Clin Psychiatry, 2001. 62(6): p. 453-63.

[2]. Gillman PK1. Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol. 2007 Jul;151(6):737-48.

Chemical & Physical Properties

[ Boiling Point ]:
64.0-65.0 °C at 760 mmHg

[ Melting Point ]:
162-164ºC

[ Molecular Formula ]:
C₁₉H₁₉D₃ClNO

[ Molecular Weight ]:
318.856

[ Flash Point ]:
9℃

[ Exact Mass ]:
318.157837

[ PSA ]:
12.47000

[ LogP ]:
4.76440

[ Storage condition ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere

[ Stability ]:
Store in Freezer at -20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
11-23/24/25-39/23/24/25

[ Safety Phrases ]:
7-16-36/37-45

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution