Arnicolide D

Names

[ Name ]:
Arnicolide D

[Synonym ]:
11alpha,13-dihydrohelenalinmethacrylate
11,13-Dihydrohelenalin methacrylate
Arnicolide D

Biological Activity

[Description]:

Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR

Signaling Pathways >> Stem Cell/Wnt >> STAT

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> STAT

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

Signaling Pathways >> Apoptosis >> Caspase

Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[Target]

Caspase

PI3K

Akt

mTOR

STAT3

[References]

[1]. Liu R, et al. Arnicolide D, from the herb Centipeda minima, Is a Therapeutic Candidate against Nasopharyngeal Carcinoma. Molecules. 2019 May 17;24(10).

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₄O₅

[ Molecular Weight ]:
332.39100

[ Exact Mass ]:
332.16200

[ PSA ]:
69.67000

[ LogP ]:
2.45320

Related Compounds

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