34532-68-8

34532-68-8 structure

Name: Arnicolide D
Chemical Name: [(1S,3aR,5R,5aR,8aR,9S,9aR)-1,5,8a-trimethyl-2,8-dioxo-3a,4,5,5a,9,9a-hexahydro-1H-azuleno[6,5-b]furan-9-yl] 2-methylprop-2-enoate
CAS Number: 34532-68-8
Molecular Formula: C₁₉H₂₄O₅
Molecular Weight: 332.39100
Catalog: Signaling Pathways Apoptosis Caspase
Create Date: 2017-05-27 09:31:25
Modify Date: 2024-01-12 17:48:15
Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner[1].

Name	[(1S,3aR,5R,5aR,8aR,9S,9aR)-1,5,8a-trimethyl-2,8-dioxo-3a,4,5,5a,9,9a-hexahydro-1H-azuleno[6,5-b]furan-9-yl] 2-methylprop-2-enoate
Synonyms	11alpha,13-dihydrohelenalinmethacrylate 11,13-Dihydrohelenalin methacrylate Arnicolide D

Description	Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	Caspase PI3K Akt mTOR STAT3
References	[1]. Liu R, et al. Arnicolide D, from the herb Centipeda minima, Is a Therapeutic Candidate against Nasopharyngeal Carcinoma. Molecules. 2019 May 17;24(10).