Sophoranol

Names

[ Name ]:
Sophoranol

[Synonym ]:
(+)-5-hydroxymatrine
5-Hydroxy-matrin
sophoranol
5-hydroxy-matridin-15-one
5-Hydroxy-matridin-15-on
Sophoranol

Biological Activity

[Description]:

Sophoranol is an alkaloid that can be isolated from S. flavescens, with antiviral activity. Sophoranol has anti-HBV (hepatitis B virus) activity. Sophoranol shows potent antiviral activities against respiratory syncytial virus (RSV) with an IC50 of 10.4 μg/mL[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

Signaling Pathways >> Anti-infection >> RSV

[Target]

IC50: 10.4 μg/mL (RSV)[2]

[In Vitro]

Sophoranol has a remarkable inhibitory effect on the secretion of HBsAg and HBeAg n in the 2.2.15 cell line[1].

[References]

[1]. Guan Ye, et al. LC-MS characterization of efficacy substances in serum of experimental animals treated with Sophora flavescens extracts. Biomed Chromatogr. 2007 Jun;21(6):655-60.

[2]. Shuang-Cheng Ma, et al. Antiviral Chinese medicinal herbs against respiratory syncytial virus. J Ethnopharmacol. 2002 Feb;79(2):205-11.

Chemical & Physical Properties

[ Density]:
1.25

[ Melting Point ]:
169-170 ºC

[ Molecular Formula ]:
C₁₅H₂₄N₂O₂

[ Molecular Weight ]:
264.36300

[ Exact Mass ]:
264.18400

[ PSA ]:
43.78000

[ LogP ]:
0.86240

[ Storage condition ]:
2-8°C