Benzolamide

Names

[ Name ]:
Benzolamide

[Synonym ]:
3dbu
benzenesulfonylamino-[1,3,4]thiadiazole-2-sulfonic acid amide
5-phenylsulfonamide-1,3,4-thiadiazole-2-sulfonamide
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
W 1803
2-(Phenylsulfonylamino)-1,3,4-thiadiazole-5-sulfonamide
5-benzenesulfonamido-1,3,4-thiadiazol-2-sulfonamide
1,3,4-Thiadiazole-2-sulfonamide,5-((phenylsulfonyl)amino)
D8W
2-benzenesulfonamido-1,3,4-thiadiazole-5-sulfonamide
Benzolamide (BZA)
BENZOLAMIDE

Biological Activity

[Description]:

Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures[1][2][3].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

Research Areas >> Neurological Disease

[Target]

Ki: 15 nM (hCA I), 9 nM (hCA II), 94 nM (EcoCAγ), 78 nM (VchCAγ), 54 nM (CAS3)[1][2]

[In Vitro]

Benzolamide inhibits hCA I, hCA II, EcoCAγ and VchCAγ, with Kis of 15 nM, 9 nM, 94 nM and 78 nM, respectively[1]. Benzolamide shows selectivity for CAS3 (Ki=54 nM) over CAS1 (Ki=2115 nM) and CAS2 (Ki=410 nM)[2].

[In Vivo]

Benzolamide (90 µmol/kg; i.p.) decreases brain pH and suppresses electrographic post-asphyxia seizures in rats[3]. Animal Model: Male and female Wistar Han rats (11-day-old)[3] Dosage: 90 µmol/kg Administration: A single i.p. Result: Induced a fast brain acidosis of a comparable magnitude. Suppressed electrographic seizures after asphyxia by slowing down the recovery of brain pH.

[References]

[1]. Prete SD, et, al. Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1545-1554.

[2]. Vullo D, et, al. Sulfonamide Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora. Molecules. 2020 Feb 25;25(5):1036.

[3]. Pospelov AS, et, al. Carbonic anhydrase inhibitors suppress seizures in a rat model of birth asphyxia. Epilepsia. 2021 Jun 27.

Chemical & Physical Properties

[ Density]:
1.746g/cm3

[ Boiling Point ]:
585.9ºC at 760mmHg

[ Molecular Formula ]:
C₈H₈N₄O₄S₃

[ Molecular Weight ]:
320.36900

[ Flash Point ]:
308.2ºC

[ Exact Mass ]:
319.97100

[ PSA ]:
177.11000

[ LogP ]:
2.92120

[ Index of Refraction ]:
1.689

[ Storage condition ]:
2-8°C

Safety Information

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Related Compounds

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