3368-13-6

3368-13-6 structure

Name: Benzolamide
Chemical Name: 5-(benzenesulfonamido)-1,3,4-thiadiazole-2-sulfonamide
CAS Number: 3368-13-6
Molecular Formula: C₈H₈N₄O₄S₃
Molecular Weight: 320.36900
Catalog: Signaling Pathways Metabolic Enzyme/Protease Carbonic Anhydrase
Create Date: 2018-08-19 12:23:16
Modify Date: 2024-01-13 17:11:29
Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures[1][2][3].

Name	5-(benzenesulfonamido)-1,3,4-thiadiazole-2-sulfonamide
Synonyms	3dbu benzenesulfonylamino-[1,3,4]thiadiazole-2-sulfonic acid amide 5-phenylsulfonamide-1,3,4-thiadiazole-2-sulfonamide 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide W 1803 2-(Phenylsulfonylamino)-1,3,4-thiadiazole-5-sulfonamide 5-benzenesulfonamido-1,3,4-thiadiazol-2-sulfonamide 1,3,4-Thiadiazole-2-sulfonamide,5-((phenylsulfonyl)amino) D8W 2-benzenesulfonamido-1,3,4-thiadiazole-5-sulfonamide Benzolamide (BZA) BENZOLAMIDE

Description	Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures[1][2][3].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase Research Areas >> Neurological Disease
Target	Ki: 15 nM (hCA I), 9 nM (hCA II), 94 nM (EcoCAγ), 78 nM (VchCAγ), 54 nM (CAS3)[1][2]
In Vitro	Benzolamide inhibits hCA I, hCA II, EcoCAγ and VchCAγ, with Kis of 15 nM, 9 nM, 94 nM and 78 nM, respectively[1]. Benzolamide shows selectivity for CAS3 (Ki=54 nM) over CAS1 (Ki=2115 nM) and CAS2 (Ki=410 nM)[2].
In Vivo	Benzolamide (90 µmol/kg; i.p.) decreases brain pH and suppresses electrographic post-asphyxia seizures in rats[3]. Animal Model: Male and female Wistar Han rats (11-day-old)[3] Dosage: 90 µmol/kg Administration: A single i.p. Result: Induced a fast brain acidosis of a comparable magnitude. Suppressed electrographic seizures after asphyxia by slowing down the recovery of brain pH.
References	[1]. Prete SD, et, al. Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1545-1554. [2]. Vullo D, et, al. Sulfonamide Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora. Molecules. 2020 Feb 25;25(5):1036. [3]. Pospelov AS, et, al. Carbonic anhydrase inhibitors suppress seizures in a rat model of birth asphyxia. Epilepsia. 2021 Jun 27.

Density	1.746g/cm3
Boiling Point	585.9ºC at 760mmHg
Molecular Formula	C₈H₈N₄O₄S₃
Molecular Weight	320.36900
Flash Point	308.2ºC
Exact Mass	319.97100
PSA	177.11000
LogP	2.92120
Index of Refraction	1.689
Storage condition	2-8°C

HS Code	2935009090

14949-00-9

98-09-9

~16%

3368-13-6

Literature: Xiao, Zhonghai; Duan, Ruifeng; Cui, Wenyu; Zhang, Yanfang; Zhang, Shouguo; Chen, Fangjin; Zhang, Yankun; Liu, Jiaying; Zhang, Dongxiang; Meng, Yuan; Wang, Lin; Wang, Hai Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 10 p. 3221 - 3228

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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