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4-nitrocatechol

Names

[ CAS No. ]:
3316-09-4

[ Name ]:
4-nitrocatechol

[Synonym ]:
EINECS 222-009-0
1,2-Benzenediol, 4-nitro-
1,2-dihydroxy-4-nitrobenzene
[14C]-4-Nitrocatechol
NITROCATECHOL (MIX OF ISOMERS)
4-nitrocathecol
3,4-dihydroxynitrobenzene
4-Nitro-1,2-benzenediol
4-nitrocatechol
4-Nitrobenzol-1,2-diol
MFCD00007242
4-Nitropyrocatechol
4-nitrobenzene-1,2-diol

Biological Activity

[Description]:

4-Nitrocatechol is a potent lipoxygenase inhibitor[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

[Target]

Human Endogenous Metabolite

Microbial Metabolite


[References]

[1]. Ewa Skrzypczak-Jankun, et al. Soybean lipoxygenase-3 in complex with 4-nitrocatechol. Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):613-5.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
358.2±32.0 °C at 760 mmHg

[ Melting Point ]:
173-177 °C(lit.)

[ Molecular Formula ]:
C6H5NO4

[ Molecular Weight ]:
155.108

[ Flash Point ]:
168.8±13.6 °C

[ Exact Mass ]:
155.021851

[ PSA ]:
86.28000

[ LogP ]:
1.68

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.668

MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2908999090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2908999090

[ Summary ]:
2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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Drug Metab. Dispos. 43(1) , 126-39, (2014)

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Related Compounds

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