COLCHICINE, O(sup 1)-DEMETHYL-, ACETATE

Names

[ CAS No. ]:
3306-60-3

[ Name ]:
COLCHICINE, O(sup 1)-DEMETHYL-, ACETATE

[Synonym ]:
1-O-acetyl-1-O-demethyl-colchicine
1-Demethyl-1-acetylcolchicine

Chemical & Physical Properties

[ Density]:
1.29g/cm3

[ Boiling Point ]:
729.6ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₅NO₇

[ Molecular Weight ]:
427.44700

[ Flash Point ]:
395ºC

[ Exact Mass ]:
427.16300

[ PSA ]:
100.16000

[ LogP ]:
3.17920

[ Index of Refraction ]:
1.587

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0881000

CHEMICAL NAME :: Colchicine, O(sup 1)-demethyl-, acetate

CAS REGISTRY NUMBER :: 3306-60-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H25-N-O7

MOLECULAR WEIGHT :: 427.49

WISWESSER LINE NOTATION :: L B677 MV&T&J COV1 DO1 EO1 JMV1 OO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 88 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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