Bz-RS-iSer(3-Ph)-OMe

Names

[ Name ]:
Bz-RS-iSer(3-Ph)-OMe

[Synonym ]:
Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate
Methyl (2R,3S)-N-Benzoyl-3-Phenylisoserine
Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, methyl ester, (αR,βS)-
MFCD00673331

Biological Activity

[Description]:

Bz-RS-iSer(3-Ph)-OMe (compound 2), a Taxol derivative, inhibits HSV replication cycle at low cytotoxicity, blocks mitotic divisions of Vero cells, influences M-MSV induced tumor size and affects immune response by inhibiting PHA-induced T lymphocyte proliferation[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

[References]

[1]. Krawczyk E, et al. Cytotoxic, antiviral (in-vitro and in-vivo), immunomodulatory activity and influence on mitotic divisions of three taxol derivatives: 10-deacetyl-baccatin III, methyl (N-benzoyl-(2'R,3'S)-3'-phenylisoserinate) and N-benzoyl-(2'R,3'S)-3'-phenylisoserine. J Pharm Pharmacol. 2005;57(6):791‐797.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
540.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₇NO₄

[ Molecular Weight ]:
299.321

[ Flash Point ]:
280.6±30.1 °C

[ Exact Mass ]:
299.115753

[ PSA ]:
75.63000

[ LogP ]:
2.90

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.588

[ Storage condition ]:
-20℃

Safety Information

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

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