A1AR antagonist 6

Names

[ CAS No. ]:
329693-22-3

[ Name ]:
A1AR antagonist 6

Biological Activity

[Description]:

A1AR antagonist 6 (compound 15) is a potent and selective A1AR (A1 adenosine receptor) antagonist, with a pIC50 of 6.38 and a pKi of 7.13[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

hA1AR:7.13 (pKi)

hA2AAR:<4 (pKi)


[References]

[1]. Wei Y, et al. Identification of new potent A1 adenosine receptor antagonists using a multistage virtual screening approach. Eur J Med Chem. 2020 Feb 1;187:111936.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H15N3O2

[ Molecular Weight ]:
293.32

Related Compounds

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