CXCR4 antagonist 6

Names

[ CAS No. ]:
2304750-68-1

[ Name ]:
CXCR4 antagonist 6

Biological Activity

[Description]:

CXCR4 antagonist 6 (compound 46) is a potent CXCR4 antagonist with an IC50 value of 79 nM. CXCR4 antagonist 6 inhibits CXCL12 induced cytosolic calcium flux (IC50 = 0.25 nM). CXCR4 antagonist 6 significantly mitigates CXCL12/CXCR4 mediated cell migration. CXCR4 antagonist 6 exhibits marked efficacy in a cancer metastasis model in mice[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> CXCR
Signaling Pathways >> Immunology/Inflammation >> CXCR

[Target]

CXCR4:79 nM (IC50)


[References]

[1]. Li Z, et al. Design, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity. Eur J Med Chem. 2020;205:112537.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H30N6

[ Molecular Weight ]:
366.50

Related Compounds