WNK1-IN-1

Names

[ Name ]:
WNK1-IN-1

Biological Activity

[Description]:

WNK1-IN-1 is a selective inhibitor of WNK1 with an IC50 value of 1.6 μM. WNK1-IN-1 inhibits OSR1 phosphorylation with an IC50 value of 4.3 μM. WNK1-IN-1 can be used for the research of blood pressure regulation and cancer[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

[Target]

IC50: 1.6 μM (WNK1), 4.3 μM (OSR1 phosphorylation)[1]

[In Vitro]

WNK1-IN-1 (0-1000 μM; 30 min) shows high potency to WNK1 with an IC50 value of 1.6 μM[1]. WNK1-IN-1 (0.2-12.5 μM; 24 h) inhibits endogenous OSR1 phosphorylation with an IC50 value of 4.3 μM in MDAMB231 breast-cancer cells[1]. WNK1-IN-1 (0-100 mM) is 10-fold more potent to WNK1 than WNK3 in Kinase-Glo assay[1].

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₅BrCl₂N₂O₄S

[ Molecular Weight ]:
446.14

WNK1-IN-1

Names

Biological Activity

Chemical & Physical Properties

Related Compounds