324022-39-1
324022-39-1 structure
- Name: WNK1-IN-1
- Chemical Name: WNK1-IN-1
- CAS Number: 324022-39-1
- Molecular Formula: C13H15BrCl2N2O4S
- Molecular Weight: 446.14
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Ser/Thr Protease
- Create Date: 2022-11-22 20:44:38
- Modify Date: 2024-01-14 10:28:31
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WNK1-IN-1 is a selective inhibitor of WNK1 with an IC50 value of 1.6 μM. WNK1-IN-1 inhibits OSR1 phosphorylation with an IC50 value of 4.3 μM. WNK1-IN-1 can be used for the research of blood pressure regulation and cancer[1].
| Name | WNK1-IN-1 |
|---|
| Description | WNK1-IN-1 is a selective inhibitor of WNK1 with an IC50 value of 1.6 μM. WNK1-IN-1 inhibits OSR1 phosphorylation with an IC50 value of 4.3 μM. WNK1-IN-1 can be used for the research of blood pressure regulation and cancer[1]. |
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| Related Catalog | |
| Target |
IC50: 1.6 μM (WNK1), 4.3 μM (OSR1 phosphorylation)[1] |
| In Vitro | WNK1-IN-1 (0-1000 μM; 30 min) shows high potency to WNK1 with an IC50 value of 1.6 μM[1]. WNK1-IN-1 (0.2-12.5 μM; 24 h) inhibits endogenous OSR1 phosphorylation with an IC50 value of 4.3 μM in MDAMB231 breast-cancer cells[1]. WNK1-IN-1 (0-100 mM) is 10-fold more potent to WNK1 than WNK3 in Kinase-Glo assay[1]. |
| Molecular Formula | C13H15BrCl2N2O4S |
|---|---|
| Molecular Weight | 446.14 |