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4-Acetoxyphenol

Names

[ CAS No. ]:
3233-32-7

[ Name ]:
4-Acetoxyphenol

[Synonym ]:
p-acetoxyphenol
p-hydroxyphenyl acetate
4-Acetoxyphenol
1,4-Benzenediol,monoacetate
(4-hydroxyphenyl) acetate
hydroquinone acetate
4-hydroxyphenylacetat
4-Hydroxyphenyl acetate
hydroquinone monoacetate

Biological Activity

[Description]:

4-Hydroxyphenyl acetate (4-HPA) is a natural antioxidant and protects cells from oxidative stress-induced necrosis. 4-Hydroxyphenyl acetate blocks the increase of cellular ROS induced by oxidative stress, and up-regulates NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor[1].

[Related Catalog]:

Research Areas >> Others

[Target]

Human Endogenous Metabolite


[In Vitro]

4-Hydroxyphenyl acetate (5 μM; 24 h) protects retinal pigment epithelial (RPE) cells from oxidative stress-induced cell death[1]. 4-Hydroxyphenyl acetate (5 μM; 24 h; ARPE-19 cells) inhibits the increase of ROS in response to oxidative stress and up-regulated the expression of cytoprotective genes including NQO1 and HO-1 genes[1]. Cell Viability Assay[1] Cell Line: ARPE-19 cells Concentration: 5 μM Incubation Time: 24 hours Result: Protected up to 89%, 92%, and 90% of ARPE-19 cells exposed to 100, 200, and 300 μM tBHP, respectively.

Chemical & Physical Properties

[ Density]:
1.212g/cm3

[ Boiling Point ]:
269.3ºC at 760 mmHg

[ Molecular Formula ]:
C8H8O3

[ Molecular Weight ]:
152.14700

[ Flash Point ]:
118.6ºC

[ Exact Mass ]:
152.04700

[ PSA ]:
46.53000

[ LogP ]:
1.31750

[ Index of Refraction ]:
1.541

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

Related Compounds