Nicotinic acid mononucleotide

Names

[ CAS No. ]:
321-02-8

[ Name ]:
Nicotinic acid mononucleotide

[Synonym ]:
3-Carboxy-1-methylpyridiniumiodid
Pyridinium,3-carboxy-1-methyl-,iodide
Trigonelline hydriodide
trigonelline hydroiodide
nicotinic acid mononucleotide
Nicotinsaeure-iodmethylat
Nicotinsaeure-mononucleotid
nicotinic acid methiodide
nicotinate adenine mononucleotide
3-Carboxy-1-methyl-pyridinium,Jodid
3-carboxy-1-methyl-pyridinium,iodide

Biological Activity

[Description]:

Nicotinic acid mononucleotide (NAMN) is formed from nicotinic acid (NA) via the nicotinic acid phosphoribosyltransferase in the biosynthesis of NAD+. Nicotinate mononucleotide is a substrate for nicotinamide mononucleotide/Nicotinic acid mononucleotide adenylyltransferase[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. O'Hara JK, et al. Targeting NAD+ metabolism in the human malaria parasite Plasmodium falciparum. PLoS One. 2014 Apr 18;9(4):e94061.

[2]. Khan JA, et al. Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery. Expert Opin Ther Targets. 2007 May;11(5):695-705.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₄NO₉P

[ Molecular Weight ]:
336.21200

[ Exact Mass ]:
336.04800

[ PSA ]:
167.44000

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Precursor & DownStream

Precursor

DownStream

Articles

ArsAB, a novel enzyme from Sporomusa ovata activates phenolic bases for adenosylcobamide biosynthesis.

Mol. Microbiol. 81(4) , 952-67, (2011)

In the homoacetogenic bacterium Sporomusa ovata, phenol and p-cresol are converted into α-ribotides, which are incorporated into biologically active cobamides (Cbas) whose lower ligand bases do not fo...

Dissecting cobamide diversity through structural and functional analyses of the base-activating CobT enzyme of Salmonella enterica.

Biochim. Biophys. Acta 1840(1) , 464-75, (2014)

Cobamide diversity arises from the nature of the nucleotide base. Nicotinate mononucleotide (NaMN):base phosphoribosyltransferases (CobT) synthesize α-linked riboside monophosphates from diverse nucle...

Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis.

Biochimie 94(2) , 300-9, (2012)

Nicotinate phosphoribosyltransferase (NaPRT, EC 2.4.2.11) catalyzes the conversion of nicotinate (Na) to nicotinate mononucleotide, the first reaction of the Preiss-Handler pathway for the biosynthesi...

Related Compounds

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