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TCS 2314

Names

[ CAS No. ]:
317353-73-4

[ Name ]:
TCS 2314

[Synonym ]:
BX 513 hydrochloride

Biological Activity

[Description]:

TCS 2314 is a very late antigen-4 (VLA-4, α4β1, CD49d/CD29) antagonist with an IC50 of 4.4 nM[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[Target]

IC50: 4.4 nM (Very late antigen-4)[1]


[References]

[1]. Muro F, et al. Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J Med Chem. 2009 Dec 24;52(24):7974-92.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H34N4O6

[ Molecular Weight ]:
522.59

[ Exact Mass ]:
522.24800

[ PSA ]:
131.77000

[ LogP ]:
3.08460

Related Compounds