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TCS JNK 6o

Names

[ CAS No. ]:
894804-07-0

[ Name ]:
TCS JNK 6o

[Synonym ]:
IN1283
benzeneacetamide, N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy-
aminopyridine deriv. 2
HMS3229K06
JNK Inhibitor VIII
Kinome_3020
N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2-(2,5-dimethoxyphenyl)acetamide

Biological Activity

[Description]:

JNK Inhibitor VIII (TCS JNK 6o) is a c-Jun N-terminal kinases (JNK-1, -2, and -3) inhibitor with ki values of 2 nM, 4 nM, 52 nM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> JNK

[Target]

JNK1:2 nM (Ki)

JNK2:4 nM (Ki)

JNK3:52 nM (Ki)


[In Vitro]

JNK Inhibitor VIII (TCS JNK 6o) shows over 1000- fold selective for JNK-1 and -2 over other MAP kinases including ERK2, p38α, and p38δ[1].

[References]

[1]. Szczepankiewicz BG, et al. Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
658.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H20N4O4

[ Molecular Weight ]:
356.38

[ Flash Point ]:
352.1±31.5 °C

[ Exact Mass ]:
356.148468

[ PSA ]:
122.72000

[ LogP ]:
4.86

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.599

[ Storage condition ]:
2-8℃

Related Compounds