4-Chloro-5-sulfamoylanthranilic Acid

[ Density]:
1.726g/cm3

[ Boiling Point ]:
549.2ºC at 760mmHg

[ Melting Point ]:
267°C (dec.) (lit.)

[ Molecular Formula ]:
C₇H₇ClN₂O₄S

[ Molecular Weight ]:
250.65900

[ Flash Point ]:
286ºC

[ Exact Mass ]:
249.98200

[ PSA ]:
131.86000

[ LogP ]:
2.63010

[ Index of Refraction ]:
1.665

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
N

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2935009090

Click to get detail synthetic route

Precursor

DownStream

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

The use of HPLC to elucidate the metabolism and urinary excretion of furosemide and its metabolic products.

Acta Pharmacol. Toxicol. (Copenh.) 49(3) , 223-9, (1981)

Three principles for the use of HPLC with spectrophotometric detection to determine the concentration of furosemide and of 4-chloro-5-sulfamoyl anthranilic acid (CSA) were studied. A reversed phase mi...

The binding of furosemide to serum proteins in elderly patients: displacing effect of phenprocoumon.

Acta Pharmacol. Toxicol. (Copenh.) 47(3) , 202-7, (1980)

The percentual binding of furosemide (5 micrograms/ml) was slightly but significantly lower in serum from elderly patients than in serum from normal blood donors (96.5 +/- 0.7 versus 97.9 +/- 0.3). A ...

Furosemide accelerates gentamicin accumulation in cultured renal cells (LLC-PK1 cells).

Nephron 53(2) , 138-41, (1989)

Furosemide is known to potentiate gentamicin nephrotoxicity. The mechanism of potentiation is unclear. In our previous studies, we demonstrated that furosemide enhanced gentamicin accumulation in rabb...

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