L-Tyrosine-d2-1

Names

[ CAS No. ]:
30811-19-9

[ Name ]:
L-Tyrosine-d2-1

[Synonym ]:
<3',5'-2H2>-L-tyrosine
3,5-d2-tyrosine
L-4-Hydroxyphenyl-3,5-d2-alanine
L-Tyrosine-3,5-d
L-<3,5-D2>-tyrosine
MFCD00144699
L-(3,5-H)Tyrosine

Biological Activity

[Description]:

L-Tyrosine-d2-1 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

[Related Catalog]:

Research Areas >> Neurological Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
385.2±32.0 °C at 760 mmHg

[ Melting Point ]:
>300ºC (dec.)(lit.)

[ Molecular Formula ]:
C9H9D2NO3

[ Molecular Weight ]:
183.201

[ Flash Point ]:
186.7±25.1 °C

[ Exact Mass ]:
183.086441

[ PSA ]:
83.55000

[ LogP ]:
0.38

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.614

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26;S36

[ RIDADR ]:
NONH for all modes of transport

Precursor & DownStream

Precursor

DownStream

Related Compounds