WAY 170523

Names

[ Name ]:
WAY 170523

Biological Activity

[Description]:

WAY-170523 is a potent and selective MMP-13 (matrix metalloproteinase-13) inhibitor, with an IC50 of 17 nM. WAY-170523 can directly attenuate ERK1/2 phosphorylation. WAY-170523 inhibits the invasion of PC-3 cells, can be used for prostate cancer research[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[Target]

MMP13:17 nM (IC50)

MMP-1:10 μM (IC50)

MMP-9:945 nM (IC50)

[In Vitro]

WAY-170523 has an IC50 of 17 nM for MMP-13 and shows > 5800-, 56-, and > 500-fold selectivity against MMP-I, MMP-9, and TACE, respectively.

[References]

[1]. James M. Chen, et al. Structure-Based Design of a Novel, Potent, and Selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer-Aided Molecular Design. J. Am. Chem. Soc. 2000, 122, 40, 9648-9654.

[2]. Mervi Toriseva, et al. Phenotypic screening using AMIDA identifies different drug responses in breast and prostate cancer cell lines in an organotypic cell culture model. Cancer Res (2018) 78 (13_Supplement): 1158.

Chemical & Physical Properties

[ Density]:
1.352g/cm3

[ Molecular Formula ]:
C₃₃H₃₁N₃O₇S

[ Molecular Weight ]:
613.68

[ Exact Mass ]:
613.18800

[ PSA ]:
146.56000

[ LogP ]:
7.23550

[ Index of Refraction ]:
1.656

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.