WAY-123398

Names

[ CAS No. ]:
138490-53-6

[ Name ]:
WAY-123398

[Synonym ]:
N-methyl-N-<2-<methyl(1-methyl-1H-benzimidazol-2-yl)amino>ethyl>-4-<(methylsulfonyl)amino>benzenesulfonamide
N-Methyl-N-(2-(methyl(1-methyl-1H-benzimidazol-2-yl)amino)ethyl)-4-((methylsulfonyl)amino)benzenesulfonamide hcl
Way-123,398
Benzenesulfonamide,N-methyl-N-(2-(methyl(1-methyl-1H-benzimidazol-2-yl)amino)ethyl)-4-((methylsulfonyl)amino)

Biological Activity

[Description]:

WAY-123398 is a class III antiarrhythmic agent. WAY-123398 is a selective blocker of the delayed rectifier K+ current[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[References]

[1]. Spinelli W, et al. Cellular electrophysiology of WAY-123,398, a new class III antiarrhythmic agent: specificity of IK block and lack of reverse use dependence in cat ventricular myocytes. Cardiovasc Res. 1993 Sep;27(9):1580-91.  

[2]. Spinelli W,et al. Effects of WAY-123,398, a new class III antiarrhythmic agent, on cardiac refractoriness and ventricular fibrillation threshold in anesthetized dogs: a comparison with UK-68798, E-4031, and dl-sotalol. J Cardiovasc Pharmacol. 1992 Dec;20(6):913-22.  

Chemical & Physical Properties

[ Density]:
1.36g/cm3

[ Boiling Point ]:
637.9ºC at 760 mmHg

[ Molecular Formula ]:
C19H25N5O4S2

[ Molecular Weight ]:
451.56300

[ Flash Point ]:
339.6ºC

[ Exact Mass ]:
451.13500

[ PSA ]:
121.37000

[ LogP ]:
3.93630

[ Vapour Pressure ]:
3.57E-16mmHg at 25°C

[ Index of Refraction ]:
1.638