3,3'-Diethyl-9-methylthiacarbocyanine iodide

Names

[ Name ]:
3,3'-Diethyl-9-methylthiacarbocyanine iodide

[Synonym ]:
3,3′-Diethyl-9-methylthiacarbocyanine iodide
Benzothiazolium,3-ethyl-2-(3-(3-ethyl-2(3H)-benzothiazolylidene)-2-methyl-1-propenyl)-,iodide
3-ethyl-2-[3-(3-ethyl-3H-benzothiazol-2-ylidene)-2-methyl-propenyl]-benzothiazolium,iodide
1,3-Bis-(3-aethyl-benzothiazol-2-yl)-2-methyl-trimethinium,Jodid
MFCD00011955
3,3'-Diethyl-9-methylthiocarbocyanin Iodid (11b)
Benzothiazolium,3-ethyl-2-(3-(3-ethyl-2-benzothiazolinylidene)-2-methyl-1-propenyl)-,iodide
1,3-bis-(3-ethyl-benzothiazol-2-yl)-2-methyl-trimethinium,iodide
3,3'-Diethyl-9-methylthiacarbocyanine iodide
T0500-8750
3-Ethyl-2-(3-(3-ethyl-3H-benzothiazol-2-ylidene)-2-methylprop-1-enyl)benzothiazolium iodide
3-ethyl-2-[3-(3-ethyl-3H-2-benzothiazolylidene)-2-methyl-1-propenyl] benzothiazolium iodide
EINECS 221-317-2

Biological Activity

[Description]:

3,3'-Diethyl-9-methylthiacarbocyanine iodide is a cyanine dye, also a tau aggregation inhibitor, with an IC50 value of 0.28 μM for tau. 3,3'-Diethyl-9-methylthiacarbocyanine iodide can cause misfunction of the microtubule cytoskeleton. 3,3'-Diethyl-9-methylthiacarbocyanine iodide can be used for researching Alzheimer’s disease[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

Research Areas >> Neurological Disease

[Target]

IC50: 0.28 μM (tau)[1]

[References]

[1]. Chang E, et al. Structure-activity relationship of cyanine tau aggregation inhibitors. J Med Chem. 2009 Jun 11;52(11):3539-47.

Chemical & Physical Properties

[ Melting Point ]:
290ºC(dec.)(lit.)

[ Molecular Formula ]:
C₂₂H₂₃IN₂S₂

[ Molecular Weight ]:
506.46600

[ Exact Mass ]:
506.03500

[ PSA ]:
65.29000

[ LogP ]:
2.41390

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL7047000

CHEMICAL NAME :: Benzothiazolium, 3-ethyl-2-(3-(3-ethyl-2-benzothiazolinylidene)-2-meth yl-1-propenyl)-, iodide

CAS REGISTRY NUMBER :: 3065-79-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H23-N2-S2.I

MOLECULAR WEIGHT :: 506.49

WISWESSER LINE NOTATION :: T56 BNYSJ B2 CU2U1- CT56 BK DSJ B2 G1 &I

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03432

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S36

[ WGK Germany ]:
3

[ RTECS ]:
DL7047000

Synthetic Route

Click to get detail synthetic route

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.