2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyl-5-iodo-

Names

[ Name ]:
2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyl-5-iodo-

[Synonym ]:
5-Iodoarabinouridine

Biological Activity

[Description]:

1-Beta-D-arabinofuranosyl-5-iodouracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
2.27g/cm3

[ Molecular Formula ]:
C₉H₁₁IN₂O₆

[ Molecular Weight ]:
370.10

[ Exact Mass ]:
369.96600

[ PSA ]:
124.78000

[ Index of Refraction ]:
1.748

2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyl-5-iodo-

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream