NSC 613948

Names

[ Name ]:
NSC 613948

[Synonym ]:
8-(hydroxymethyl)-3,7-dimethyl-3,7-dihydro-1h-purine-2,6-dione
8-Hydroxymethyl-theobromin
8-Hydroxymethyl-3,7-dimethyl-3,7-dihydro-purin-2,6-dion
8-Hydroxymethyl-6,11-dimethyl-11H-oxazolo[5,4,3-ij]pyrido[3,2-g]chinolin-4,10-dion
8-hydroxymethyl-3,7-dimethyl-3,7-dihydro-purine-2,6-dione
8-Hydroxymethyltheobromine
8-hydroxymethyl-6,11-dimethyl-11H-oxazolo[5,4,3-ij]pyrido[3,2-g]quinoline-4,10-dione

Biological Activity

[Description]:

Nybomycin, an antibiotic, exhibits antiphage and antibacterial properties. Nybomycin binds to DNA and induces a unique morphological change to mycobacterial bacilli leading the bacterial cell death[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Strelitz F, et, al. NYBOMYCIN, A NEW ANTIBIOTIC WITH ANTIPHAGE AND ANTIBACTERIAL PROPERTIES. Proc Natl Acad Sci U S A. 1955 Sep 15;41(9):620-4.

[2]. Arai M, et, al. Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp. Bioorg Med Chem. 2015 Jul 1;23(13):3534-41.

Chemical & Physical Properties

[ Density]:
1.54g/cm3

[ Boiling Point ]:
538.7ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₄N₂O₄

[ Molecular Weight ]:
298.29300

[ Flash Point ]:
279.6ºC

[ Exact Mass ]:
298.09500

[ PSA ]:
73.46000

[ LogP ]:
1.00400

[ Vapour Pressure ]:
1.95E-12mmHg at 25°C

[ Index of Refraction ]:
1.737

Synthetic Route

Click to get detail synthetic route

Related Compounds

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