MRGPRX1 agonist 2

Names

[ CAS No. ]:
302952-43-8

[ Name ]:
MRGPRX1 agonist 2

Biological Activity

[Description]:

MRGPRX1 agonist 2 (compound 1a) is a potent Mas-related G protein-coupled receptor X1 (MRGPRX1) positive allosteric modulator with an EC50 value of 0.48 μM. MRGPRX1 agonist 2 can be used for researching neuropathic pain[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[Target]

EC50: 0.48 μM (MRGPRX1)[1]


[References]

[1]. Berhane I, et al. Thieno[2,3-d]pyrimidine-Based Positive Allosteric Modulators of Human Mas-Related G Protein-Coupled Receptor X1 (MRGPRX1). J Med Chem. 2022;65(4):3218-3228.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H14N2OS

[ Molecular Weight ]:
270.35

Related Compounds