5-Aminocarbonylmethyl-2-thiouridine

Names

[ CAS No. ]:
29900-40-1

[ Name ]:
5-Aminocarbonylmethyl-2-thiouridine

[Synonym ]:
4(1H)-Pyrimidinone, 5-(2-amino-2-oxoethyl)-2,3-dihydro-1-β-D-ribofuranosyl-2-thioxo-
5-(2-Amino-2-oxoethyl)-1-(β-D-ribofuranosyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone

Biological Activity

[Description]:

5-Aminocarbonylmethyl-2-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Molecular Formula ]:
C11H15N3O6S

[ Molecular Weight ]:
317.32

[ Exact Mass ]:
317.068146

[ LogP ]:
-1.84

[ Index of Refraction ]:
1.727

Related Compounds

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