H-Gly-Sar-OH

Names

[ Name ]:
H-Gly-Sar-OH

[Synonym ]:
2-(2-Amino-N-methylacetamido)acetic acid
N-glycyl-sarcosine
MFCD00038193
Glycylsarcosine
Glycyl-sarcosine
H-Gly-Sar-OH
Gly-Sarcosin
Gly-Sar
EINECS 249-875-2

Biological Activity

[Description]:

Gly-Sar is a Glycine (HY-Y0966) derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
1.284g/cm3

[ Boiling Point ]:
333.5ºC at 760mmHg

[ Melting Point ]:
198-202 °C (dec.)

[ Molecular Formula ]:
C₅H₁₀N₂O₃

[ Molecular Weight ]:
146.14400

[ Flash Point ]:
155.5ºC

[ Exact Mass ]:
146.06900

[ PSA ]:
83.63000

[ Vapour Pressure ]:
2.6E-05mmHg at 25°C

[ Index of Refraction ]:
1.51

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

QSAR-based permeability model for drug-like compounds.

Bioorg. Med. Chem. 19 , 2615-24, (2011)

A QSAR model was developed for predicting intestinal drug permeability, one of the most important parameters when evaluating compounds in drug discovery projects. First, a set of relevant properties f...

Intestinal absorption mechanisms of MTBH, a novel hesperetin derivative, in Caco-2 cells, and potential involvement of monocarboxylate transporter 1 and multidrug resistance protein 2.

Eur. J. Pharm. Sci. 78 , 214-24, (2015)

Hesperetin, the aglycone of hesperidin, occurs naturally in citrus fruits. It exerts extensive pharmacological activities. However, hesperetin's poor solubility and low bioavailability limit its wide ...

Mechanistic insights into PEPT1-mediated transport of a novel antiepileptic, NP-647.

Mol. Pharm. 9(9) , 2458-68, (2012)

The present study, in general, is aimed to uncover the properties of the transport mechanism or mechanisms responsible for the uptake of NP-647 into Caco-2 cells and, in particular, to understand whet...