5'-O-Trt-Zidovudine

Names

[ Name ]:
5'-O-Trt-Zidovudine

[Synonym ]:
3-Azido-3-deoxy-5-O-triphenylmethylthymidine
3'-Azido-3'-deoxy-5'-O-tritylthymidine
Thymidine,3'-azido-3'-deoxy-5'-O-trityl-(8CI)
Thymidine,3'-azido-3'-deoxy-5'-O-(triphenylmethyl)
5'-O-Trt-Zidovudine

Biological Activity

[Description]:

3′-Azido-3′-deoxy-5′-O-(triphenylmethyl)thymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Melting Point ]:
103-104 °C(Solv: toluene (108-88-3))

[ Molecular Formula ]:
C₂₉H₂₇N₅O₄

[ Molecular Weight ]:
509.56

[ Exact Mass ]:
509.20600

[ PSA ]:
123.33000

[ LogP ]:
4.68516

[ Storage condition ]:
2-8℃

5'-O-Trt-Zidovudine

Names

Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Precursor

DownStream

Related Compounds