PI3Kα-IN-13

Names

[ Name ]:
PI3Kα-IN-13

Biological Activity

[Description]:

PI3Kα-IN-13 (Compound 18a) is a PI3Kα inhibitor (IC50: 2.5 nM). PI3Kα-IN-13 induces tumor cell apoptosis. PI3Kα-IN-13 inhibits cancer cell proliferation with IC50s of 0.75 μM (MCF-7), 3.79 μM (HCT-116), 13.71 μM (MDA-MB-231), 9.85 μM (SW620), respectively. PI3Kα-IN-13 inhibits tumor cell colony formation, migration and invasion[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[Target]

PI3Kα

[References]

[1]. Zheng XM, et al. Design, synthesis and bioevaluation of PI3Kα-selective inhibitors as potential colorectal cancer drugs. Eur J Med Chem. 2023 Nov 15;260:115754.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₉N₅O₃

[ Molecular Weight ]:
389.41

Related Compounds

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