2955529-67-4

2955529-67-4 structure

Name: PI3Kα-IN-13
Chemical Name: PI3Kα-IN-13
CAS Number: 2955529-67-4
Molecular Formula: C₂₁H₁₉N₅O₃
Molecular Weight: 389.41
Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
Create Date: 2023-11-26 19:58:15
Modify Date: 2024-01-29 18:01:10
PI3Kα-IN-13 (Compound 18a) is a PI3Kα inhibitor (IC50: 2.5 nM). PI3Kα-IN-13 induces tumor cell apoptosis. PI3Kα-IN-13 inhibits cancer cell proliferation with IC50s of 0.75 μM (MCF-7), 3.79 μM (HCT-116), 13.71 μM (MDA-MB-231), 9.85 μM (SW620), respectively. PI3Kα-IN-13 inhibits tumor cell colony formation, migration and invasion[1].

Name	PI3Kα-IN-13

Description	PI3Kα-IN-13 (Compound 18a) is a PI3Kα inhibitor (IC50: 2.5 nM). PI3Kα-IN-13 induces tumor cell apoptosis. PI3Kα-IN-13 inhibits cancer cell proliferation with IC50s of 0.75 μM (MCF-7), 3.79 μM (HCT-116), 13.71 μM (MDA-MB-231), 9.85 μM (SW620), respectively. PI3Kα-IN-13 inhibits tumor cell colony formation, migration and invasion[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	PI3Kα
References	[1]. Zheng XM, et al. Design, synthesis and bioevaluation of PI3Kα-selective inhibitors as potential colorectal cancer drugs. Eur J Med Chem. 2023 Nov 15;260:115754.

Molecular Formula	C₂₁H₁₉N₅O₃
Molecular Weight	389.41