MY-673

Names

[ CAS No. ]:
2944459-96-3

[ Name ]:
MY-673

Biological Activity

[Description]:

MY-673 is a colchicine binding site inhibitor (CBSI), that inhibits tubulin polymerization. MY-673 inhibits the ERK signaling pathway, which in turn affects SMAD4 protein expression levels in the TGF-β/SMAD pathway. MY-673 inhibited cell proliferation, migration and induced apoptosis in vivo and in vitro[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad
Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Signaling Pathways >> MAPK/ERK Pathway >> ERK
Signaling Pathways >> Stem Cell/Wnt >> ERK

[References]

[1]. Song J, et al. Discovery of a novel Coumarin-Dihydroquinoxalone derivative MY-673 as a tubulin polymerization inhibitor capable of inhibiting the ERK pathway with potent anti-gastric cancer activities. Bioorg Chem. 2023 Aug;137:106580.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H14N2O4

[ Molecular Weight ]:
322.31

Related Compounds

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