Ack1 inhibitor 1

Names

[ CAS No. ]:
2924415-92-7

[ Name ]:
Ack1 inhibitor 1

Biological Activity

[Description]:

Ack1 inhibitor 1 is a potent, selective, and orally active inhibitor of ACK1 kinase with an IC50 value of 2.1 nM. Ack1 inhibitor 1 inhibits the phosphorylation of ACK1 and activation of downstream AKT. Ack1 inhibitor 1 has anti-tumor activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Ack1
Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[References]

[1]. Li Q, et al. Design, Synthesis, and Evaluation of (R)-8-((Tetrahydrofuran-2-yl)methyl)pyrido[2,3-d]pyrimidin-7-ones as Novel Selective ACK1 Inhibitors to Combat Acquired Resistance to the Third-Generation EGFR Inhibitor. J Med Chem. 2023 May 25;66(10):6905-6921.  

Chemical & Physical Properties

[ Molecular Formula ]:
C39H40F3N7O4

[ Molecular Weight ]:
727.77

Related Compounds

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