2924415-92-7

2924415-92-7 structure

Name: Ack1 inhibitor 1
Chemical Name: Ack1 inhibitor 1
CAS Number: 2924415-92-7
Molecular Formula: C₃₉H₄₀F₃N₇O₄
Molecular Weight: 727.77
Catalog: Signaling Pathways PI3K/Akt/mTOR Akt
Create Date: 2023-10-09 13:13:04
Modify Date: 2024-01-08 10:21:11
Ack1 inhibitor 1 is a potent, selective, and orally active inhibitor of ACK1 kinase with an IC50 value of 2.1 nM. Ack1 inhibitor 1 inhibits the phosphorylation of ACK1 and activation of downstream AKT. Ack1 inhibitor 1 has anti-tumor activity[1].

Name	Ack1 inhibitor 1

Description	Ack1 inhibitor 1 is a potent, selective, and orally active inhibitor of ACK1 kinase with an IC50 value of 2.1 nM. Ack1 inhibitor 1 inhibits the phosphorylation of ACK1 and activation of downstream AKT. Ack1 inhibitor 1 has anti-tumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Ack1 Signaling Pathways >> PI3K/Akt/mTOR >> Akt
References	[1]. Li Q, et al. Design, Synthesis, and Evaluation of (R)-8-((Tetrahydrofuran-2-yl)methyl)pyrido[2,3-d]pyrimidin-7-ones as Novel Selective ACK1 Inhibitors to Combat Acquired Resistance to the Third-Generation EGFR Inhibitor. J Med Chem. 2023 May 25;66(10):6905-6921.

Molecular Formula	C₃₉H₄₀F₃N₇O₄
Molecular Weight	727.77